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SEPT9 Methylation Blood Test for Colon Cancer

California rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated July 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$63.10

Typical negotiated rate. In California, July 2026.

Insurers have agreed to pay about $63.10 for this service. The price depends on where it is billed: about $126 from a physician practice, and about $45.71 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 10 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$126$70.79 to $224
FacilityA hospital or hospital-owned outpatient department$45.71$38.02 to $162

How much rates vary

Facilitymedian $46 · 10th to 90th $33 to $407Professionalmedian $126 · 10th to 90th $55 to $813
$20.0$100.0$500.0$2.0Kfacility $46professional $126

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$117.49
Median
$288.40
Typical High
$707.95
Aetna
Setting
Professional
Modifier
Global
Typical Low
$54.95
Median
$154.88
Typical High
$1,258.93
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$33.11
Median
$42.66
Typical High
$181.97
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$72.44
Median
$87.10
Typical High
$323.59
Blue Shield
Setting
Facility
Modifier
Global
Typical Low
$87.10
Median
$416.87
Typical High
$831.76
Blue Shield
Setting
Professional
Modifier
Global
Typical Low
$54.95
Median
$70.79
Typical High
$117.49
Cigna
Setting
Facility
Modifier
Global
Typical Low
$69.18
Median
$331.13
Typical High
$676.08
Cigna
Setting
Professional
Modifier
Global
Typical Low
$44.67
Median
$107.15
Typical High
$338.84
Contra Costa Health
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$208.93
Typical High
$257.04
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$208.93
Typical High
$363.08
Lucent Health
Setting
Facility
Modifier
Global
Typical Low
$912.01
Median
$912.01
Typical High
$912.01
Lucent Health
Setting
Professional
Modifier
Global
Typical Low
$954.99
Median
$1,445.44
Typical High
$1,445.44
Providence
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$229.09
Typical High
$501.19
Providence
Setting
Professional
Modifier
Global
Typical Low
$44.67
Median
$114.82
Typical High
$338.84
Sutter Health Plus
Setting
Professional
Modifier
Global
Typical Low
$676.08
Median
$676.08
Typical High
$676.08
United
Setting
Facility
Modifier
Global
Typical Low
$81.28
Median
$190.55
Typical High
$218.78
United
Setting
Professional
Modifier
Global
Typical Low
$35.48
Median
$81.28
Typical High
$398.11

Where California sits

The same service costs 6.9 times more in Alaska than in California. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

California $63.10 · 51st of 51
AK $437CA $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.