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SEPT9 Methylation Blood Test for Colon Cancer

Pennsylvania rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated July 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$162

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $162 for this service. The price depends on where it is billed: about $155 from a physician practice, and about $288 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$155$75.86 to $162
FacilityA hospital or hospital-owned outpatient department$288$162 to $479

How much rates vary

Facilitymedian $288 · 10th to 90th $162 to $661Professionalmedian $155 · 10th to 90th $46 to $398
$100.0$1.0K$10.0Kfacility $288professional $155

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$162.18
Median
$295.12
Typical High
$676.08
Aetna
Setting
Professional
Modifier
Global
Typical Low
$45.71
Median
$154.88
Typical High
$676.08
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$302.00
Median
$407.38
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$151.36
Typical High
$151.36
Cigna
Setting
Facility
Modifier
Global
Typical Low
$138.04
Median
$316.23
Typical High
$660.69
Cigna
Setting
Professional
Modifier
Global
Typical Low
$38.90
Median
$77.62
Typical High
$251.19
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$134.90
Typical High
$251.19
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$190.55
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$63.10
Median
$158.49
Typical High
$338.84
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$154.88
Median
$288.40
Typical High
$660.69
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$45.71
Median
$154.88
Typical High
$676.08
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$478.63
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$208.93
United
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$190.55
Typical High
$229.09
United
Setting
Professional
Modifier
Global
Typical Low
$79.43
Median
$114.82
Typical High
$257.04

Where Pennsylvania sits

The same service costs 6.9 times more in Alaska than in California. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Pennsylvania $162 · 30th of 51
AK $437CA $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.