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SEPT9 Methylation Blood Test for Colon Cancer

Minnesota rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$191

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $191 for this service. The price depends on where it is billed: about $191 from a physician practice, and about $191 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$191$155 to $229
FacilityA hospital or hospital-owned outpatient department$191$182 to $457

How much rates vary

Facilitymedian $191 · 10th to 90th $182 to $741Professionalmedian $191 · 10th to 90th $91 to $372
$50$100$200$500$1Kfacility $191professional $191

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$181.97
Median
$181.97
Typical High
$181.97
Aetna
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$181.97
Typical High
$186.21
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$181.97
Median
$190.55
Typical High
$446.68
BCBS Minnesota
Setting
Professional
Modifier
None
Typical Low
$154.88
Median
$173.78
Typical High
$190.55
Cigna
Setting
Facility
Modifier
None
Typical Low
$380.19
Median
$616.60
Typical High
$1,778.28
Cigna
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$251.19
Typical High
$371.54
Health Partners
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$588.84
Typical High
$1,412.54
Health Partners
Setting
Professional
Modifier
None
Typical Low
$218.78
Median
$218.78
Typical High
$338.84
Medica
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$275.42
Typical High
$380.19
Medica
Setting
Professional
Modifier
None
Typical Low
$42.66
Median
$173.78
Typical High
$954.99
United
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$190.55
Typical High
$229.09
United
Setting
Professional
Modifier
None
Typical Low
$42.66
Median
$114.82
Typical High
$446.68
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$91.20
Median
$91.20
Typical High
$91.20
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$36.31
Median
$36.31
Typical High
$36.31
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$91.20
Median
$91.20
Typical High
$91.20
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$36.31
Median
$36.31
Typical High
$37.15

Where Minnesota sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 18th of 51

$191

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.