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SEPT9 Methylation Blood Test for Colon Cancer

South Carolina rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$151

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $151 for this service. The price depends on where it is billed: about $151 from a physician practice, and about $389 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$151$83.18 to $191
FacilityA hospital or hospital-owned outpatient department$389$204 to $871

How much rates vary

Facilitymedian $389 · 10th to 90th $151 to $1,175Professionalmedian $151 · 10th to 90th $42 to $204
$50$100$200$500$1Kfacility $389professional $151

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$151.36
Median
$151.36
Typical High
$151.36
Aetna
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$151.36
Typical High
$154.88
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$1,023.29
Median
$1,023.29
Typical High
$1,071.52
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$190.55
Typical High
$208.93
Cigna
Setting
Facility
Modifier
None
Typical Low
$338.84
Median
$398.11
Typical High
$1,174.90
Cigna
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$87.10
Typical High
$199.53
Medcost
Setting
Facility
Modifier
None
Typical Low
$79.43
Median
$165.96
Typical High
$549.54
Medcost
Setting
Professional
Modifier
None
Typical Low
$83.18
Median
$83.18
Typical High
$251.19
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$229.09
United
Setting
Professional
Modifier
None
Typical Low
$41.69
Median
$81.28
Typical High
$154.88
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$74.13
Median
$74.13
Typical High
$77.62
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$30.20
Median
$30.20
Typical High
$30.90
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$41.69
Median
$41.69
Typical High
$144.54

Where South Carolina sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 26th of 51

$151

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.