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SEPT9 Methylation Blood Test for Colon Cancer

Colorado rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$251

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $251 for this service. The price depends on where it is billed: about $100 from a physician practice, and about $562 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$100$81.28 to $240
FacilityA hospital or hospital-owned outpatient department$562$372 to $661

How much rates vary

Facilitymedian $562 · 10th to 90th $148 to $871Professionalmedian $100 · 10th to 90th $47 to $398
$50$100$200$500$1Kfacility $562professional $100

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$407.38
Typical High
$891.25
Aetna
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$144.54
Typical High
$204.17
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$575.44
Typical High
$870.96
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$81.28
Median
$81.28
Typical High
$426.58
Cigna
Setting
Facility
Modifier
None
Typical Low
$112.20
Median
$234.42
Typical High
$602.56
Cigna
Setting
Professional
Modifier
None
Typical Low
$37.15
Median
$93.33
Typical High
$275.42
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$131.83
Median
$144.54
Typical High
$208.93
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$275.42
Typical High
$407.38
Select Health
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$354.81
Typical High
$407.38
Select Health
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$190.55
Typical High
$288.40
United
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
United
Setting
Professional
Modifier
None
Typical Low
$35.48
Median
$81.28
Typical High
$114.82
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$67.61
Median
$72.44
Typical High
$102.33
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.92
Median
$29.51
Typical High
$40.74

Where Colorado sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 6th of 51

$251

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.