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SEPT9 Methylation Blood Test for Colon Cancer

Florida rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated July 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$138

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $138 for this service. The price depends on where it is billed: about $135 from a physician practice, and about $229 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$135$54.95 to $155
FacilityA hospital or hospital-owned outpatient department$229$174 to $525

How much rates vary

Facilitymedian $229 · 10th to 90th $138 to $776Professionalmedian $135 · 10th to 90th $50 to $191
$5.0$20.0$100.0$500.0facility $229professional $135

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$138.04
Median
$229.09
Typical High
$954.99
Aetna
Setting
Professional
Modifier
Global
Typical Low
$50.12
Median
$134.90
Typical High
$173.78
AvMed
Setting
Facility
Modifier
Global
Typical Low
$169.82
Median
$190.55
Typical High
$223.87
AvMed
Setting
Professional
Modifier
Global
Typical Low
$14.13
Median
$190.55
Typical High
$190.55
Cigna
Setting
Facility
Modifier
Global
Typical Low
$48.98
Median
$72.44
Typical High
$776.25
Cigna
Setting
Professional
Modifier
Global
Typical Low
$41.69
Median
$100.00
Typical High
$281.84
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$354.81
Median
$354.81
Typical High
$354.81
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$70.79
Median
$114.82
Typical High
$114.82
Molina
Setting
Professional
Modifier
Global
Typical Low
$83.18
Median
$114.82
Typical High
$190.55
United
Setting
Facility
Modifier
Global
Typical Low
$45.71
Median
$114.82
Typical High
$190.55
United
Setting
Professional
Modifier
Global
Typical Low
$35.48
Median
$81.28
Typical High
$218.78
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$114.82
Median
$190.55
Typical High
$190.55

Where Florida sits

The same service costs 6.9 times more in Alaska than in California. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Florida $138 · 45th of 51
AK $437CA $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.