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CYP2D6 Drug Metabolism Gene Test

Nebraska rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$295

Typical negotiated rate. In Nebraska, October 2026.

Insurers have agreed to pay about $295 for this service. The price depends on where it is billed: about $269 from a physician practice, and about $603 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$269$269 to $851
FacilityA hospital or hospital-owned outpatient department$603$468 to $1,072

How much rates vary

Facilitymedian $603 · 10th to 90th $269 to $1,259Professionalmedian $269 · 10th to 90th $257 to $2,239
$200$500$1K$2Kfacility $603professional $269

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$295.12
Median
$1,071.52
Typical High
$2,238.72
Aetna
Setting
Professional
Modifier
None
Typical Low
$295.12
Median
$295.12
Typical High
$1,071.52
BCBS Nebraska
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$602.56
Typical High
$1,230.27
Cigna
Setting
Professional
Modifier
None
Typical Low
$831.76
Median
$851.14
Typical High
$1,071.52
Medica
Setting
Facility
Modifier
None
Typical Low
$162.18
Median
$562.34
Typical High
$2,137.96
Medica
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$269.15
Typical High
$2,238.72
Midlands
Setting
Professional
Modifier
None
Typical Low
$831.76
Median
$831.76
Typical High
$831.76
Midlands
Setting
Professional
Modifier
None
Typical Low
$831.76
Median
$831.76
Typical High
$831.76
United
Setting
Facility
Modifier
None
Typical Low
$162.18
Median
$190.55
Typical High
$269.15
United
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$269.15
Typical High
$1,348.96

Where Nebraska sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Nebraska· 49th of 51

$295

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.