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CYP2D6 Drug Metabolism Gene Test

Nebraska rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated July 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$646

Typical negotiated rate. In Nebraska, July 2026.

Insurers have agreed to pay about $646 for this service. The price depends on where it is billed: about $295 from a physician practice, and about $1,202 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$295$295 to $1,259
FacilityA hospital or hospital-owned outpatient department$1,202$468 to $2,754

How much rates vary

Facilitymedian $1,202 · 10th to 90th $295 to $3,981Professionalmedian $295 · 10th to 90th $269 to $2,951
$200.0$500.0$1.0K$2.0Kfacility $1,202professional $295

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$912.01
Median
$1,348.96
Typical High
$3,981.07
Aetna
Setting
Professional
Modifier
Global
Typical Low
$295.12
Median
$295.12
Typical High
$2,951.21
BCBS
Setting
Facility
Modifier
Global
Typical Low
$446.68
Median
$575.44
Typical High
$1,230.27
BCBS
Setting
Professional
Modifier
Global
Typical Low
$645.65
Median
$707.95
Typical High
$741.31
Cigna
Setting
Professional
Modifier
Global
Typical Low
$537.03
Median
$870.96
Typical High
$1,071.52
Medica
Setting
Facility
Modifier
Global
Typical Low
$269.15
Median
$676.08
Typical High
$2,137.96
Medica
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$269.15
Typical High
$1,318.26
Midlands
Setting
Professional
Modifier
Global
Typical Low
$933.25
Median
$933.25
Typical High
$933.25
United
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$426.58
Typical High
$446.68
United
Setting
Professional
Modifier
Global
Typical Low
$257.04
Median
$269.15
Typical High
$1,258.93

Where Nebraska sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Nebraska $646 · 5th of 51
AK $1,023VT $269

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.