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CYP2D6 Drug Metabolism Gene Test

Michigan rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$427

Typical negotiated rate. In Michigan, October 2026.

Insurers have agreed to pay about $427 for this service. The price depends on where it is billed: about $427 from a physician practice, and about $427 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$427$339 to $447
FacilityA hospital or hospital-owned outpatient department$427$427 to $537

How much rates vary

Facilitymedian $427 · 10th to 90th $339 to $794Professionalmedian $427 · 10th to 90th $257 to $537
$10$20$50$100$200$500$1Kfacility $427professional $427

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$660.69
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$213.80
Median
$213.80
Typical High
$331.13
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$85.11
Median
$85.11
Typical High
$134.90
Aetna
Setting
Professional
Modifier
None
Typical Low
$389.05
Median
$446.68
Typical High
$457.09
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$204.17
Median
$218.78
Typical High
$229.09
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$83.18
Median
$89.13
Typical High
$91.20
BCBS Michigan
Setting
Facility
Modifier
None
Typical Low
$10.96
Median
$338.84
Typical High
$338.84
BCBS Michigan
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$338.84
Typical High
$338.84
CareSource
Setting
Professional
Modifier
None
Typical Low
$446.68
Median
$501.19
Typical High
$602.56
Cigna
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$257.04
Typical High
$616.60
Health Alliance Plan
Setting
Facility
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$1,230.27
Health Alliance Plan
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$213.80
Median
$213.80
Typical High
$331.13
Health Alliance Plan
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$85.11
Median
$85.11
Typical High
$134.90
Health Alliance Plan
Setting
Professional
Modifier
None
Typical Low
$380.19
Median
$426.58
Typical High
$562.34
Health Alliance Plan
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$213.80
Median
$213.80
Typical High
$213.80
Health Alliance Plan
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$85.11
Median
$85.11
Typical High
$85.11
Priority Health
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$257.04
Typical High
$616.60
United
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$407.38
Typical High
$537.03
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$446.68

Where Michigan sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Michigan· 29th of 51

$427

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.