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CYP2D6 Drug Metabolism Gene Test

Missouri rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$398

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $398 for this service. The price depends on where it is billed: about $380 from a physician practice, and about $776 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$380$191 to $603
FacilityA hospital or hospital-owned outpatient department$776$479 to $1,549

How much rates vary

Facilitymedian $776 · 10th to 90th $407 to $2,138Professionalmedian $380 · 10th to 90th $112 to $1,148
$100$200$500$1K$2Kfacility $776professional $380

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$380.19
Median
$575.44
Typical High
$831.76
Aetna
Setting
Professional
Modifier
None
Typical Low
$331.13
Median
$389.05
Typical High
$478.63
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$446.68
Typical High
$2,089.30
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$112.20
Median
$295.12
Typical High
$812.83
BCBS Kansas City
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$446.68
Typical High
$851.14
Cigna
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$1,000.00
Typical High
$1,905.46
Cigna
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$501.19
Typical High
$645.65
Medica
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$776.25
Typical High
$2,137.96
Medica
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$446.68
Typical High
$2,238.72
United
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$407.38
Typical High
$407.38
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$602.56
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$190.55
Median
$194.98
Typical High
$257.04
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$75.86
Median
$77.62
Typical High
$104.71

Where Missouri sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 33rd of 51

$398

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.