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CYP2D6 Drug Metabolism Gene Test

Missouri rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated July 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$437

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $437 for this service. The price depends on where it is billed: about $380 from a physician practice, and about $589 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$380$224 to $513
FacilityA hospital or hospital-owned outpatient department$589$447 to $776

How much rates vary

Facilitymedian $589 · 10th to 90th $407 to $1,047Professionalmedian $380 · 10th to 90th $182 to $813
$10.0$50.0$200.0$1.0Kfacility $589professional $380

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$436.52
Median
$758.58
Typical High
$1,047.13
Aetna
Setting
Professional
Modifier
Global
Typical Low
$346.74
Median
$389.05
Typical High
$912.01
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$398.11
Median
$398.11
Typical High
$398.11
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$446.68
Median
$446.68
Typical High
$1,584.89
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$57.54
Median
$181.97
Typical High
$724.44
BCBS
Setting
Professional
Modifier
Global
Typical Low
$316.23
Median
$446.68
Typical High
$501.19
Cigna
Setting
Facility
Modifier
Global
Typical Low
$316.23
Median
$870.96
Typical High
$1,905.46
Cigna
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$354.81
Typical High
$645.65
Medica
Setting
Facility
Modifier
Global
Typical Low
$380.19
Median
$537.03
Typical High
$2,137.96
Medica
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$269.15
Typical High
$2,238.72
United
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$446.68
Typical High
$537.03
United
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$269.15
Typical High
$602.56

Where Missouri sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Missouri $437 · 26th of 51
AK $1,023VT $269

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.