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CYP2D6 Drug Metabolism Gene Test

Colorado rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$603

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $603 for this service. The price depends on where it is billed: about $269 from a physician practice, and about $1,318 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$269$191 to $589
FacilityA hospital or hospital-owned outpatient department$1,318$851 to $1,549

How much rates vary

Facilitymedian $1,318 · 10th to 90th $347 to $2,042Professionalmedian $269 · 10th to 90th $191 to $933
$200$500$1K$2Kfacility $1,318professional $269

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$457.09
Median
$954.99
Typical High
$2,089.30
Aetna
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$338.84
Typical High
$478.63
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$478.63
Median
$1,348.96
Typical High
$2,041.74
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$190.55
Typical High
$1,000.00
Cigna
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$549.54
Typical High
$1,412.54
Cigna
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$239.88
Typical High
$660.69
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$338.84
Median
$407.38
Typical High
$562.34
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$446.68
Median
$645.65
Typical High
$1,148.15
Select Health
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$831.76
Typical High
$954.99
Select Health
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$446.68
Typical High
$676.08
United
Setting
Facility
Modifier
None
Typical Low
$537.03
Median
$537.03
Typical High
$537.03
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$190.55
Typical High
$331.13
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$158.49
Median
$169.82
Typical High
$239.88
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$63.10
Median
$69.18
Typical High
$95.50

Where Colorado sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 5th of 51

$603

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.