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CYP2D6 Drug Metabolism Gene Test

Colorado rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated July 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$479

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $479 for this service. The price depends on where it is billed: about $339 from a physician practice, and about $1,096 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$339$269 to $363
FacilityA hospital or hospital-owned outpatient department$1,096$603 to $1,862

How much rates vary

Facilitymedian $1,096 · 10th to 90th $347 to $2,291Professionalmedian $339 · 10th to 90th $191 to $479
$200.0$500.0$1.0K$2.0K$5.0K$10.0Kfacility $1,096professional $339

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$281.84
Median
$977.24
Typical High
$2,137.96
Aetna
Setting
Professional
Modifier
Global
Typical Low
$275.42
Median
$338.84
Typical High
$478.63
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$562.34
Median
$1,348.96
Typical High
$2,290.87
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$181.97
Median
$190.55
Typical High
$446.68
Cigna
Setting
Facility
Modifier
Global
Typical Low
$263.03
Median
$295.12
Typical High
$1,174.90
Cigna
Setting
Professional
Modifier
Global
Typical Low
$208.93
Median
$239.88
Typical High
$660.69
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$323.59
Median
$446.68
Typical High
$676.08
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$630.96
Median
$645.65
Typical High
$1,230.27
Select Health
Setting
Facility
Modifier
Global
Typical Low
$478.63
Median
$831.76
Typical High
$954.99
Select Health
Setting
Professional
Modifier
Global
Typical Low
$316.23
Median
$446.68
Typical High
$676.08
United
Setting
Facility
Modifier
Global
Typical Low
$407.38
Median
$446.68
Typical High
$676.08
United
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$269.15

Where Colorado sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Colorado $479 · 13th of 51
AK $1,023VT $269

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.