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CYP2D6 Drug Metabolism Gene Test

Illinois rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$347

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $347 for this service. The price depends on where it is billed: about $316 from a physician practice, and about $832 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$316$4.37 to $355
FacilityA hospital or hospital-owned outpatient department$832$603 to $1,585

How much rates vary

Facilitymedian $832 · 10th to 90th $479 to $2,884Professionalmedian $316 · 10th to 90th $3 to $537
$10$100$1Kfacility $832professional $316

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$371.54
Median
$707.95
Typical High
$1,348.96
Aetna
Setting
Professional
Modifier
None
Typical Low
$354.81
Median
$371.54
Typical High
$407.38
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$537.03
Median
$794.33
Typical High
$5,623.41
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$309.03
Typical High
$346.74
Cigna
Setting
Facility
Modifier
None
Typical Low
$501.19
Median
$933.25
Typical High
$1,862.09
Cigna
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$549.54
Typical High
$741.31
Hally Health
Setting
Professional
Modifier
None
Typical Low
$446.68
Median
$676.08
Typical High
$1,122.02
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$588.84
Median
$588.84
Typical High
$588.84
United
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$537.03
Typical High
$562.34
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$446.68
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$186.21
Median
$323.59
Typical High
$676.08
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$74.13
Median
$131.83
Typical High
$275.42
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$181.97
Median
$186.21
Typical High
$204.17
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$72.44
Median
$74.13
Typical High
$81.28

Where Illinois sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 42nd of 51

$347

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.