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CYP2D6 Drug Metabolism Gene Test

Virginia rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$380

Typical negotiated rate. In Virginia, October 2026.

Insurers have agreed to pay about $380 for this service. The price depends on where it is billed: about $324 from a physician practice, and about $617 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$324$251 to $447
FacilityA hospital or hospital-owned outpatient department$617$447 to $1,072

How much rates vary

Facilitymedian $617 · 10th to 90th $447 to $2,239Professionalmedian $324 · 10th to 90th $191 to $661
$100$200$500$1K$2K$5K$10Kfacility $617professional $324

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$338.84
Median
$380.19
Typical High
$1,047.13
Aetna
Setting
Professional
Modifier
None
Typical Low
$338.84
Median
$338.84
Typical High
$380.19
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$446.68
Typical High
$2,187.76
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$239.88
Typical High
$323.59
CareFirst
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$363.08
Typical High
$426.58
Cigna
Setting
Facility
Modifier
None
Typical Low
$457.09
Median
$870.96
Typical High
$1,513.56
Cigna
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$323.59
Typical High
$758.58
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$501.19
Typical High
$630.96
Medcost
Setting
Facility
Modifier
None
Typical Low
$616.60
Median
$616.60
Typical High
$812.83
Medcost
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$446.68
Typical High
$602.56
Sentara
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$630.96
Typical High
$10,232.93
Sentara
Setting
Professional
Modifier
None
Typical Low
$407.38
Median
$562.34
Typical High
$2,089.30
United
Setting
Facility
Modifier
None
Typical Low
$537.03
Median
$537.03
Typical High
$537.03
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$630.96
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$169.82
Median
$169.82
Typical High
$190.55
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$67.61
Median
$67.61
Typical High
$75.86

Where Virginia sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Virginia· 34th of 51

$380

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.