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CYP2D6 Drug Metabolism Gene Test

New York rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$427

Typical negotiated rate. In New York, October 2026.

Insurers have agreed to pay about $427 for this service. The price depends on where it is billed: about $407 from a physician practice, and about $759 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$407$245 to $575
FacilityA hospital or hospital-owned outpatient department$759$447 to $1,047

How much rates vary

Facilitymedian $759 · 10th to 90th $288 to $1,175Professionalmedian $407 · 10th to 90th $145 to $933
$20$100$500$2Kfacility $759professional $407

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$380.19
Typical High
$1,380.38
Aetna
Setting
Professional
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$380.19
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$446.68
Typical High
$1,174.90
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$371.54
Median
$630.96
Typical High
$1,122.02
CDPHP
Setting
Professional
Modifier
None
Typical Low
$446.68
Median
$446.68
Typical High
$446.68
Cigna
Setting
Facility
Modifier
None
Typical Low
$436.52
Median
$954.99
Typical High
$1,288.25
Cigna
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$549.54
Typical High
$2,187.76
Emblem Health
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$741.31
Typical High
$1,230.27
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$380.19
Typical High
$660.69
Excellus BCBS
Setting
Professional
Modifier
None
Typical Low
$363.08
Median
$426.58
Typical High
$512.86
MVP Health Care
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$257.04
Typical High
$912.01
MVP Health Care
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$144.54
Typical High
$933.25
United
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$446.68
Typical High
$562.34
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$223.87
Typical High
$676.08
Univera
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$288.40
Typical High
$478.63
Univera
Setting
Professional
Modifier
None
Typical Low
$363.08
Median
$426.58
Typical High
$501.19
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$123.03
Median
$123.03
Typical High
$190.55
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$48.98
Median
$48.98
Typical High
$75.86

Where New York sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

New York· 28th of 51

$427

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.