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CYP2D6 Drug Metabolism Gene Test

Massachusetts rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$457

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $457 for this service. The price depends on where it is billed: about $447 from a physician practice, and about $646 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$447$269 to $1,148
FacilityA hospital or hospital-owned outpatient department$646$447 to $1,072

How much rates vary

Facilitymedian $646 · 10th to 90th $331 to $1,413Professionalmedian $447 · 10th to 90th $269 to $2,239
$100$200$500$1K$2K$5Kfacility $646professional $447

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$630.96
Typical High
$1,412.54
Aetna
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$316.23
Typical High
$316.23
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$512.86
Typical High
$1,380.38
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$851.14
Typical High
$2,238.72
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$1,000.00
Typical High
$1,445.44
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$446.68
Cigna
Setting
Facility
Modifier
None
Typical Low
$295.12
Median
$549.54
Typical High
$870.96
Cigna
Setting
Professional
Modifier
None
Typical Low
$263.03
Median
$478.63
Typical High
$1,737.80
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$758.58
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$645.65
Median
$645.65
Typical High
$758.58
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$446.68
Typical High
$1,148.15
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$512.86
Typical High
$1,380.38
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$851.14
Typical High
$2,238.72
United
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$446.68
Typical High
$537.03
United
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$269.15
Typical High
$851.14
Well Sense
Setting
Facility
Modifier
None
Typical Low
$398.11
Median
$549.54
Typical High
$812.83
Well Sense
Setting
Professional
Modifier
None
Typical Low
$338.84
Median
$338.84
Typical High
$407.38
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$158.49
Median
$158.49
Typical High
$158.49
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$63.10
Median
$63.10
Typical High
$63.10
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$446.68
Median
$588.84
Typical High
$691.83

Where Massachusetts sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 20th of 51

$457

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.