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CYP2D6 Drug Metabolism Gene Test

Minnesota rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated July 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$447

Typical negotiated rate. In Minnesota, July 2026.

Insurers have agreed to pay about $447 for this service. The price depends on where it is billed: about $447 from a physician practice, and about $1,148 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$447$427 to $513
FacilityA hospital or hospital-owned outpatient department$1,148$447 to $1,698

How much rates vary

Facilitymedian $1,148 · 10th to 90th $447 to $3,311Professionalmedian $447 · 10th to 90th $363 to $661
$10.0$50.0$200.0$1.0Kfacility $1,148professional $447

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$426.58
Median
$426.58
Typical High
$426.58
Aetna
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$426.58
Typical High
$1,348.96
BCBS
Setting
Facility
Modifier
Global
Typical Low
$446.68
Median
$446.68
Typical High
$831.76
BCBS
Setting
Professional
Modifier
Global
Typical Low
$363.08
Median
$446.68
Typical High
$446.68
Cigna
Setting
Facility
Modifier
Global
Typical Low
$891.25
Median
$1,548.82
Typical High
$4,168.69
Cigna
Setting
Professional
Modifier
Global
Typical Low
$524.81
Median
$660.69
Typical High
$933.25
Health Partners
Setting
Facility
Modifier
Global
Typical Low
$1,000.00
Median
$1,445.44
Typical High
$3,311.31
Health Partners
Setting
Professional
Modifier
Global
Typical Low
$512.86
Median
$512.86
Typical High
$870.96
Medica
Setting
Facility
Modifier
Global
Typical Low
$407.38
Median
$794.33
Typical High
$1,380.38
Medica
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$269.15
Typical High
$1,202.26
United
Setting
Facility
Modifier
Global
Typical Low
$446.68
Median
$537.03
Typical High
$1,023.29
United
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$446.68
Typical High
$933.25

Where Minnesota sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Minnesota $447 · 19th of 51
AK $1,023VT $269

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.