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CYP2D6 Drug Metabolism Gene Test

Minnesota rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$447

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $447 for this service. The price depends on where it is billed: about $447 from a physician practice, and about $447 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$447$389 to $550
FacilityA hospital or hospital-owned outpatient department$447$427 to $1,096

How much rates vary

Facilitymedian $447 · 10th to 90th $427 to $1,738Professionalmedian $447 · 10th to 90th $269 to $912
$200$500$1K$2Kfacility $447professional $447

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$426.58
Aetna
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$436.52
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$426.58
Median
$446.68
Typical High
$1,096.48
BCBS Minnesota
Setting
Professional
Modifier
None
Typical Low
$363.08
Median
$407.38
Typical High
$446.68
Cigna
Setting
Facility
Modifier
None
Typical Low
$891.25
Median
$1,445.44
Typical High
$4,168.69
Cigna
Setting
Professional
Modifier
None
Typical Low
$524.81
Median
$588.84
Typical High
$870.96
Health Partners
Setting
Facility
Modifier
None
Typical Low
$851.14
Median
$1,380.38
Typical High
$3,311.31
Health Partners
Setting
Professional
Modifier
None
Typical Low
$512.86
Median
$512.86
Typical High
$870.96
Medica
Setting
Facility
Modifier
None
Typical Low
$537.03
Median
$724.44
Typical High
$933.25
Medica
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$467.74
Typical High
$2,238.72
United
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$446.68
Typical High
$537.03
United
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$363.08
Typical High
$1,047.13
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$213.80
Median
$213.80
Typical High
$213.80
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$85.11
Median
$85.11
Typical High
$85.11
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$213.80
Median
$213.80
Typical High
$218.78
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$85.11
Median
$85.11
Typical High
$87.10

Where Minnesota sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 25th of 51

$447

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.