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CYP2D6 Drug Metabolism Gene Test

Florida rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated July 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$339

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $339 for this service. The price depends on where it is billed: about $316 from a physician practice, and about $832 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$316$275 to $380
FacilityA hospital or hospital-owned outpatient department$832$407 to $1,288

How much rates vary

Facilitymedian $832 · 10th to 90th $324 to $1,820Professionalmedian $316 · 10th to 90th $204 to $479
$5.0$20.0$100.0$500.0$2.0Kfacility $832professional $316

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$338.84
Median
$1,071.52
Typical High
$2,238.72
Aetna
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$316.23
Typical High
$457.09
AvMed
Setting
Facility
Modifier
Global
Typical Low
$398.11
Median
$446.68
Typical High
$524.81
AvMed
Setting
Professional
Modifier
Global
Typical Low
$14.13
Median
$446.68
Typical High
$446.68
Cigna
Setting
Facility
Modifier
Global
Typical Low
$245.47
Median
$363.08
Typical High
$1,819.70
Cigna
Setting
Professional
Modifier
Global
Typical Low
$218.78
Median
$346.74
Typical High
$812.83
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$831.76
Median
$831.76
Typical High
$831.76
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$269.15
Typical High
$354.81
Molina
Setting
Professional
Modifier
Global
Typical Low
$54.95
Median
$60.26
Typical High
$562.34
United
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$407.38
Typical High
$562.34
United
Setting
Professional
Modifier
Global
Typical Low
$158.49
Median
$190.55
Typical High
$588.84
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$50.12
Median
$446.68
Typical High
$446.68

Where Florida sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Florida $339 · 46th of 51
AK $1,023VT $269

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.