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CYP2D6 Drug Metabolism Gene Test

Florida rates for HCPCS 81226

Examines the CYP2D6 gene, which carries the instructions for a liver enzyme that breaks down a large share of common medicines. The test checks for the usual variants, including extra or missing copies of the gene, and reports whether a person clears those drugs slowly, normally, or unusually fast.

Rates data updated October 2026.

How much does CYP2D6 Drug Metabolism Gene Test cost?

$275

Typical negotiated rate. In Florida, October 2026.

Insurers have agreed to pay about $275 for this service. The price depends on where it is billed: about $269 from a physician practice, and about $832 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$269$204 to $363
FacilityA hospital or hospital-owned outpatient department$832$575 to $832

How much rates vary

Facilitymedian $832 · 10th to 90th $363 to $832Professionalmedian $269 · 10th to 90th $158 to $513
$20$50$100$200$500$1Kfacility $832professional $269

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$275.42
Typical High
$912.01
Aetna
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$275.42
Typical High
$363.08
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$102.33
Median
$134.90
Typical High
$181.97
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$40.74
Median
$54.95
Typical High
$72.44
AvMed
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$446.68
Typical High
$549.54
AvMed
Setting
Professional
Modifier
None
Typical Low
$363.08
Median
$446.68
Typical High
$446.68
Cigna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$363.08
Typical High
$1,819.70
Cigna
Setting
Professional
Modifier
None
Typical Low
$213.80
Median
$316.23
Typical High
$812.83
Florida Blue
Setting
Facility
Modifier
None
Typical Low
$831.76
Median
$831.76
Typical High
$831.76
Florida Blue
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$269.15
Typical High
$354.81
Molina
Setting
Professional
Modifier
None
Typical Low
$60.26
Median
$60.26
Typical High
$562.34
United
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$446.68
Typical High
$446.68
United
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$194.98
Typical High
$616.60
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$446.68
Typical High
$446.68

Where Florida sits

The same service costs 3.7 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 51st of 51

$275

AK $1,023FL $275

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.