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CYP2C19 Drug Metabolism Gene Test

Maryland rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$219

Typical negotiated rate. In Maryland, July 2026.

Insurers have agreed to pay about $219 for this service. Most negotiated rates run $174 to $245.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $355 · 10th to 90th $123 to $603Professionalmedian $219 · 10th to 90th $132 to $380
$5.0$20.0$100.0$500.0$2.0Kfacility $355professional $219

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$354.81
Median
$371.54
Typical High
$602.56
Aetna
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$218.78
Typical High
$380.19
CareFirst
Setting
Professional
Modifier
Global
Typical Low
$208.93
Median
$208.93
Typical High
$263.03
Cigna
Setting
Professional
Modifier
Global
Typical Low
$158.49
Median
$181.97
Typical High
$512.86
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$288.40
Median
$346.74
Typical High
$436.52
United
Setting
Facility
Modifier
Global
Typical Low
$123.03
Median
$123.03
Typical High
$776.25
United
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$131.83
Typical High
$257.04
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$144.54
Median
$229.09
Typical High
$229.09

Where Maryland sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Maryland $219 · 47th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.