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CYP2C19 Drug Metabolism Gene Test

Illinois rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$240

Typical negotiated rate. In Illinois, July 2026.

Insurers have agreed to pay about $240 for this service. The price depends on where it is billed: about $224 from a physician practice, and about $457 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$224$162 to $275
FacilityA hospital or hospital-owned outpatient department$457$302 to $603

How much rates vary

Facilitymedian $457 · 10th to 90th $240 to $794Professionalmedian $224 · 10th to 90th $3 to $501
$10.0$100.0$1.0Kfacility $457professional $224

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$239.88
Median
$457.09
Typical High
$602.56
Aetna
Setting
Professional
Modifier
Global
Typical Low
$181.97
Median
$245.47
Typical High
$537.03
BCBS
Setting
Facility
Modifier
Global
Typical Low
$354.81
Median
$1,023.29
Typical High
$3,630.78
BCBS
Setting
Professional
Modifier
Global
Typical Low
$3.47
Median
$199.53
Typical High
$223.87
Cigna
Setting
Facility
Modifier
Global
Typical Low
$457.09
Median
$616.60
Typical High
$1,348.96
Cigna
Setting
Professional
Modifier
Global
Typical Low
$141.25
Median
$354.81
Typical High
$489.78
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$295.12
Median
$512.86
Typical High
$977.24
Hally Health
Setting
Facility
Modifier
Global
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$380.19
Median
$380.19
Typical High
$380.19
United
Setting
Facility
Modifier
Global
Typical Low
$288.40
Median
$288.40
Typical High
$588.84
United
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$173.78
Typical High
$295.12

Where Illinois sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Illinois $240 · 36th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.