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CYP2C19 Drug Metabolism Gene Test

Nebraska rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$437

Typical negotiated rate. In Nebraska, July 2026.

Insurers have agreed to pay about $437 for this service. The price depends on where it is billed: about $191 from a physician practice, and about $776 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$191$191 to $776
FacilityA hospital or hospital-owned outpatient department$776$347 to $1,778

How much rates vary

Facilitymedian $776 · 10th to 90th $191 to $2,570Professionalmedian $191 · 10th to 90th $174 to $1,905
$100.0$200.0$500.0$1.0K$2.0Kfacility $776professional $191

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$588.84
Median
$870.96
Typical High
$2,570.40
Aetna
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$1,905.46
BCBS
Setting
Facility
Modifier
Global
Typical Low
$338.84
Median
$436.52
Typical High
$851.14
BCBS
Setting
Professional
Modifier
Global
Typical Low
$416.87
Median
$457.09
Typical High
$478.63
Cigna
Setting
Professional
Modifier
Global
Typical Low
$346.74
Median
$562.34
Typical High
$691.83
Medica
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$436.52
Typical High
$1,380.38
Medica
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$173.78
Typical High
$851.14
Midlands
Setting
Professional
Modifier
Global
Typical Low
$602.56
Median
$602.56
Typical High
$602.56
United
Setting
Facility
Modifier
Global
Typical Low
$123.03
Median
$275.42
Typical High
$288.40
United
Setting
Professional
Modifier
Global
Typical Low
$165.96
Median
$173.78
Typical High
$812.83

Where Nebraska sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Nebraska $437 · 4th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.