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CYP2C19 Drug Metabolism Gene Test

Florida rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$219

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $219 for this service. The price depends on where it is billed: about $204 from a physician practice, and about $537 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$204$174 to $245
FacilityA hospital or hospital-owned outpatient department$537$263 to $832

How much rates vary

Facilitymedian $537 · 10th to 90th $219 to $1,047Professionalmedian $204 · 10th to 90th $135 to $309
$5.0$20.0$100.0$500.0facility $537professional $204

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$218.78
Median
$537.03
Typical High
$1,174.90
Aetna
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$204.17
Typical High
$295.12
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$177.83
Median
$177.83
Typical High
$177.83
AvMed
Setting
Facility
Modifier
Global
Typical Low
$257.04
Median
$288.40
Typical High
$338.84
AvMed
Setting
Professional
Modifier
Global
Typical Low
$14.13
Median
$288.40
Typical High
$288.40
Cigna
Setting
Facility
Modifier
Global
Typical Low
$158.49
Median
$234.42
Typical High
$1,174.90
Cigna
Setting
Professional
Modifier
Global
Typical Low
$141.25
Median
$223.87
Typical High
$524.81
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$537.03
Median
$537.03
Typical High
$537.03
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$128.82
Median
$173.78
Typical High
$173.78
Molina
Setting
Professional
Modifier
Global
Typical Low
$154.88
Median
$169.82
Typical High
$363.08
United
Setting
Facility
Modifier
Global
Typical Low
$123.03
Median
$263.03
Typical High
$363.08
United
Setting
Professional
Modifier
Global
Typical Low
$102.33
Median
$123.03
Typical High
$389.05
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$141.25
Median
$288.40
Typical High
$288.40

Where Florida sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Florida $219 · 48th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.