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CYP2C19 Drug Metabolism Gene Test

Ohio rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$245

Typical negotiated rate. In Ohio, July 2026.

Insurers have agreed to pay about $245 for this service. The price depends on where it is billed: about $234 from a physician practice, and about $407 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$234$141 to $275
FacilityA hospital or hospital-owned outpatient department$407$288 to $646

How much rates vary

Facilitymedian $407 · 10th to 90th $240 to $1,175Professionalmedian $234 · 10th to 90th $117 to $646
$100.0$200.0$500.0$1.0K$2.0Kfacility $407professional $234

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$234.42
Median
$524.81
Typical High
$1,174.90
Aetna
Setting
Professional
Modifier
Global
Typical Low
$234.42
Median
$234.42
Typical High
$691.83
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$269.15
Median
$309.03
Typical High
$537.03
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$117.49
Median
$144.54
Typical High
$380.19
CareSource
Setting
Facility
Modifier
Global
Typical Low
$234.42
Median
$338.84
Typical High
$407.38
CareSource
Setting
Professional
Modifier
Global
Typical Low
$288.40
Median
$288.40
Typical High
$389.05
Cigna
Setting
Facility
Modifier
Global
Typical Low
$281.84
Median
$380.19
Typical High
$1,202.26
Cigna
Setting
Professional
Modifier
Global
Typical Low
$131.83
Median
$257.04
Typical High
$645.65
Medical Mutual of Ohio
Setting
Facility
Modifier
Global
Typical Low
$309.03
Median
$389.05
Typical High
$1,202.26
Medical Mutual of Ohio
Setting
Professional
Modifier
Global
Typical Low
$131.83
Median
$165.96
Typical High
$575.44
Molina
Setting
Professional
Modifier
Global
Typical Low
$199.53
Median
$263.03
Typical High
$316.23
SummaCare
Setting
Professional
Modifier
Global
Typical Low
$245.47
Median
$323.59
Typical High
$676.08
United
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$288.40
Typical High
$436.52
United
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$173.78
Typical High
$389.05

Where Ohio sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Ohio $245 · 34th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.