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CYP2C19 Drug Metabolism Gene Test

Colorado rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated October 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$389

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $389 for this service. The price depends on where it is billed: about $174 from a physician practice, and about $851 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$174$123 to $380
FacilityA hospital or hospital-owned outpatient department$851$550 to $1,000

How much rates vary

Facilitymedian $851 · 10th to 90th $224 to $1,349Professionalmedian $174 · 10th to 90th $123 to $603
$200$500$1K$2Kfacility $851professional $174

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$295.12
Median
$616.60
Typical High
$1,348.96
Aetna
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$223.87
Typical High
$309.03
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$870.96
Typical High
$1,348.96
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$645.65
Cigna
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$354.81
Typical High
$912.01
Cigna
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$154.88
Typical High
$426.58
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$223.87
Median
$263.03
Typical High
$363.08
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$288.40
Median
$416.87
Typical High
$741.31
Select Health
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$537.03
Typical High
$616.60
Select Health
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$288.40
Typical High
$436.52
United
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$346.74
Typical High
$346.74
United
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$213.80
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$102.33
Median
$109.65
Typical High
$154.88
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$40.74
Median
$44.67
Typical High
$61.66

Where Colorado sits

The same service costs 3.8 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 4th of 51

$389

AK $661AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.