go back

CYP2C19 Drug Metabolism Gene Test

Colorado rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$309

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $309 for this service. The price depends on where it is billed: about $224 from a physician practice, and about $708 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$224$174 to $234
FacilityA hospital or hospital-owned outpatient department$708$389 to $1,202

How much rates vary

Facilitymedian $708 · 10th to 90th $224 to $1,479Professionalmedian $224 · 10th to 90th $123 to $309
$100.0$200.0$500.0$1.0K$2.0K$5.0Kfacility $708professional $224

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$181.97
Median
$645.65
Typical High
$1,380.38
Aetna
Setting
Professional
Modifier
Global
Typical Low
$177.83
Median
$223.87
Typical High
$309.03
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$363.08
Median
$870.96
Typical High
$1,479.11
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$117.49
Median
$123.03
Typical High
$288.40
Cigna
Setting
Facility
Modifier
Global
Typical Low
$169.82
Median
$190.55
Typical High
$758.58
Cigna
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$154.88
Typical High
$426.58
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$208.93
Median
$288.40
Typical High
$436.52
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$407.38
Median
$416.87
Typical High
$933.25
Select Health
Setting
Facility
Modifier
Global
Typical Low
$309.03
Median
$537.03
Typical High
$616.60
Select Health
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$288.40
Typical High
$436.52
United
Setting
Facility
Modifier
Global
Typical Low
$263.03
Median
$288.40
Typical High
$436.52
United
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$123.03
Typical High
$173.78

Where Colorado sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Colorado $309 · 15th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.