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CYP2C19 Drug Metabolism Gene Test

Hawaii rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$389

Typical negotiated rate. In Hawaii, July 2026.

Insurers have agreed to pay about $389 for this service. Most negotiated rates run $347 to $501.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $288 · 10th to 90th $240 to $347Professionalmedian $417 · 10th to 90th $295 to $589
$200.0$500.0facility $288professional $417

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$239.88
Median
$288.40
Typical High
$346.74
Aetna
Setting
Professional
Modifier
Global
Typical Low
$363.08
Median
$363.08
Typical High
$363.08
Cigna
Setting
Professional
Modifier
Global
Typical Low
$346.74
Median
$346.74
Typical High
$346.74
HMSA
Setting
Professional
Modifier
Global
Typical Low
$295.12
Median
$380.19
Typical High
$416.87
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$323.59
Median
$346.74
Typical High
$436.52
United
Setting
Professional
Modifier
Global
Typical Low
$144.54
Median
$295.12
Typical High
$416.87
University Health Alliance
Setting
Professional
Modifier
Global
Typical Low
$323.59
Median
$457.09
Typical High
$602.56

Where Hawaii sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Hawaii $389 · 6th of 51
AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.