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CYP2C19 Drug Metabolism Gene Test

Minnesota rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated July 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$288

Typical negotiated rate. In Minnesota, July 2026.

Insurers have agreed to pay about $288 for this service. The price depends on where it is billed: about $288 from a physician practice, and about $692 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$288$275 to $331
FacilityA hospital or hospital-owned outpatient department$692$288 to $1,072

How much rates vary

Facilitymedian $692 · 10th to 90th $275 to $2,138Professionalmedian $288 · 10th to 90th $234 to $447
$200$500$1K$2Kfacility $692professional $288

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$245.47
Median
$275.42
Typical High
$575.44
Aetna
Setting
Professional
Modifier
Global
Typical Low
$194.98
Median
$275.42
Typical High
$870.96
BCBS
Setting
Facility
Modifier
Global
Typical Low
$288.40
Median
$288.40
Typical High
$562.34
BCBS
Setting
Professional
Modifier
Global
Typical Low
$234.42
Median
$288.40
Typical High
$288.40
Cigna
Setting
Facility
Modifier
Global
Typical Low
$575.44
Median
$1,000.00
Typical High
$2,691.53
Cigna
Setting
Professional
Modifier
Global
Typical Low
$338.84
Median
$426.58
Typical High
$602.56
Health Partners
Setting
Facility
Modifier
Global
Typical Low
$645.65
Median
$933.25
Typical High
$2,137.96
Health Partners
Setting
Professional
Modifier
Global
Typical Low
$331.13
Median
$331.13
Typical High
$562.34
Medica
Setting
Facility
Modifier
Global
Typical Low
$263.03
Median
$512.86
Typical High
$891.25
Medica
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$173.78
Typical High
$676.08
United
Setting
Facility
Modifier
Global
Typical Low
$288.40
Median
$346.74
Typical High
$776.25
United
Setting
Professional
Modifier
Global
Typical Low
$147.91
Median
$288.40
Typical High
$630.96

Where Minnesota sits

The same service costs 3.8 times more in Alaska than in Vermont. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 20th of 51

$288

AK $661VT $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.