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CYP2C19 Drug Metabolism Gene Test

Vermont rates for HCPCS 81225

A blood or cheek-swab test that examines common variations in the CYP2C19 gene, which controls one of the liver enzymes that break medicines down. The result predicts whether a person clears certain drugs quickly, normally, or slowly, so a prescriber can pick a suitable medicine or adjust the dose. Clopidogrel, several antidepressants, and some acid-reducing medicines depend on this enzyme.

Rates data updated October 2026.

How much does CYP2C19 Drug Metabolism Gene Test cost?

$295

Typical negotiated rate. In Vermont, October 2026.

Insurers have agreed to pay about $295 for this service. Most negotiated rates run $174 to $398.

Few insurers publish rates for this combination, so treat this figure as a rough guide.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $288 · 10th to 90th $288 to $490Professionalmedian $295 · 10th to 90th $135 to $646
$200$500$1Kfacility $288professional $295

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$204.17
Cigna
Setting
Facility
Modifier
None
Typical Low
$489.78
Median
$489.78
Typical High
$489.78
Cigna
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$398.11
Typical High
$660.69
MVP Health Care
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$288.40
Typical High
$288.40
MVP Health Care
Setting
Professional
Modifier
None
Typical Low
$288.40
Median
$295.12
Typical High
$295.12
United
Setting
Professional
Modifier
None
Typical Low
$131.83
Median
$338.84
Typical High
$645.65

Where Vermont sits

The same service costs 3.8 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Vermont· 18th of 51

$295

AK $661AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.