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Whole Exome Genetic Sequencing

South Dakota rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$5,370

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $5,370 for this service. The price depends on where it is billed: about $4,786 from a physician practice, and about $5,370 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$4,786$3,715 to $9,120
FacilityA hospital or hospital-owned outpatient department$5,370$5,370 to $9,120

How much rates vary

Facilitymedian $5,370 · 10th to 90th $4,467 to $9,120Professionalmedian $4,786 · 10th to 90th $2,455 to $11,482
$2K$5K$10K$20Kfacility $5,370professional $4,786

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$3,311.31
Median
$3,311.31
Typical High
$5,495.41
Aetna
Setting
Professional
Modifier
None
Typical Low
$3,090.30
Median
$3,235.94
Typical High
$4,466.84
Cigna
Setting
Facility
Modifier
None
Typical Low
$9,120.11
Median
$9,120.11
Typical High
$9,120.11
Cigna
Setting
Professional
Modifier
None
Typical Low
$5,495.41
Median
$9,120.11
Typical High
$11,481.54
Medica
Setting
Facility
Modifier
None
Typical Low
$4,570.88
Median
$5,370.32
Typical High
$8,709.64
Medica
Setting
Professional
Modifier
None
Typical Low
$2,454.71
Median
$4,265.80
Typical High
$8,709.64
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$7,244.36
Median
$11,220.18
Typical High
$13,182.57
United
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$2,884.03
Typical High
$4,786.30
Wellmark
Setting
Professional
Modifier
None
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$4,786.30

Where South Dakota sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 10th of 51

$5,370

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.