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Whole Exome Genetic Sequencing

North Carolina rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$4,074

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $4,074 for this service. The price depends on where it is billed: about $4,074 from a physician practice, and about $4,074 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$4,074$2,884 to $5,248
FacilityA hospital or hospital-owned outpatient department$4,074$3,802 to $10,471

How much rates vary

Facilitymedian $4,074 · 10th to 90th $3,631 to $21,878Professionalmedian $4,074 · 10th to 90th $2,138 to $7,244
$2K$5K$10K$20Kfacility $4,074professional $4,074

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$3,801.89
Median
$3,801.89
Typical High
$7,943.28
Aetna
Setting
Professional
Modifier
None
Typical Low
$3,162.28
Median
$3,801.89
Typical High
$4,570.88
Ambetter
Setting
Professional
Modifier
None
Typical Low
$2,884.03
Median
$2,884.03
Typical High
$2,884.03
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$10,471.29
Median
$12,589.25
Typical High
$15,135.61
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$2,137.96
Median
$4,786.30
Typical High
$7,585.78
Cigna
Setting
Facility
Modifier
None
Typical Low
$3,801.89
Median
$10,471.29
Typical High
$21,877.62
Cigna
Setting
Professional
Modifier
None
Typical Low
$2,238.72
Median
$2,691.53
Typical High
$6,918.31
Medcost
Setting
Professional
Modifier
None
Typical Low
$4,570.88
Median
$4,570.88
Typical High
$4,570.88
Medcost
Setting
Facility
Modifier
None
Typical Low
$3,019.95
Median
$3,801.89
Typical High
$4,786.30
Medcost
Setting
Professional
Modifier
None
Typical Low
$4,677.35
Median
$4,786.30
Typical High
$8,128.31
United
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$2,398.83
Typical High
$4,786.30
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$1,905.46
Median
$1,905.46
Typical High
$2,290.87
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$758.58
Median
$758.58
Typical High
$912.01
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$2,398.83
Median
$2,398.83
Typical High
$6,606.93

Where North Carolina sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 26th of 51

$4,074

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.