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Whole Exome Genetic Sequencing

Massachusetts rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated July 2026.

How much does Whole Exome Genetic Sequencing cost?

$4,786

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $4,786 for this service. The price depends on where it is billed: about $4,786 from a physician practice, and about $6,607 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$4,786$2,884 to $4,786
FacilityA hospital or hospital-owned outpatient department$6,607$4,266 to $13,183

How much rates vary

Facilitymedian $6,607 · 10th to 90th $2,884 to $15,488Professionalmedian $4,786 · 10th to 90th $1,000 to $10,965
$1K$2K$5K$10K$20Kfacility $6,607professional $4,786

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$1,000.00
Median
$8,317.64
Typical High
$14,125.38
Aetna
Setting
Professional
Modifier
Global
Typical Low
$1,000.00
Median
$1,000.00
Typical High
$14,454.40
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$3,548.13
Median
$5,495.41
Typical High
$22,908.68
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$2,884.03
Median
$4,786.30
Typical High
$14,125.38
BCBS
Setting
Professional
Modifier
Global
Typical Low
$4,365.16
Median
$4,365.16
Typical High
$4,677.35
Cigna
Setting
Facility
Modifier
Global
Typical Low
$3,162.28
Median
$3,801.89
Typical High
$7,762.47
Cigna
Setting
Professional
Modifier
Global
Typical Low
$2,398.83
Median
$4,570.88
Typical High
$10,000.00
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$83.18
Median
$5,888.44
Typical High
$9,772.37
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$3,548.13
Median
$6,918.31
Typical High
$8,128.31
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$7,943.28
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$3,548.13
Median
$5,495.41
Typical High
$22,908.68
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$2,884.03
Median
$4,786.30
Typical High
$14,125.38
United
Setting
Facility
Modifier
Global
Typical Low
$2,630.27
Median
$4,786.30
Typical High
$5,754.40
United
Setting
Professional
Modifier
Global
Typical Low
$2,884.03
Median
$4,786.30
Typical High
$8,511.38

Where Massachusetts sits

The same service costs 7.2 times more in North Dakota than in Vermont. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 11th of 51

$4,786

ND $7,244VT $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.