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Whole Exome Genetic Sequencing

Massachusetts rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$4,786

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $4,786 for this service. The price depends on where it is billed: about $4,786 from a physician practice, and about $5,495 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$4,786$2,884 to $11,749
FacilityA hospital or hospital-owned outpatient department$5,495$3,548 to $7,244

How much rates vary

Facilitymedian $5,495 · 10th to 90th $3,548 to $11,220Professionalmedian $4,786 · 10th to 90th $1,000 to $23,988
$100$500$2K$10Kfacility $5,495professional $4,786

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$1,000.00
Median
$1,000.00
Typical High
$1,000.00
Aetna
Setting
Professional
Modifier
None
Typical Low
$1,000.00
Median
$1,000.00
Typical High
$1,000.00
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$3,548.13
Median
$5,011.87
Typical High
$14,125.38
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$7,244.36
Typical High
$23,988.33
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$4,365.16
Median
$4,365.16
Typical High
$4,365.16
Cigna
Setting
Facility
Modifier
None
Typical Low
$3,162.28
Median
$3,548.13
Typical High
$8,511.38
Cigna
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$5,011.87
Typical High
$18,620.87
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$2,951.21
Median
$6,918.31
Typical High
$8,128.31
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$6,918.31
Median
$6,918.31
Typical High
$8,128.31
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$2,398.83
Median
$4,786.30
Typical High
$10,232.93
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$3,548.13
Median
$5,011.87
Typical High
$14,125.38
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$7,244.36
Typical High
$23,988.33
United
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$4,786.30
Typical High
$5,754.40
United
Setting
Professional
Modifier
None
Typical Low
$1,905.46
Median
$2,884.03
Typical High
$9,120.11
Well Sense
Setting
Facility
Modifier
None
Typical Low
$2,511.89
Median
$5,248.07
Typical High
$8,317.64
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$501.19
Median
$501.19
Typical High
$501.19
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$199.53
Median
$199.53
Typical High
$199.53
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$4,786.30
Median
$6,165.95
Typical High
$7,413.10

Where Massachusetts sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 16th of 51

$4,786

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.