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Whole Exome Genetic Sequencing

Pennsylvania rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated July 2026.

How much does Whole Exome Genetic Sequencing cost?

$3,981

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $3,981 for this service. The price depends on where it is billed: about $3,890 from a physician practice, and about $7,079 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 10 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,890$3,020 to $4,467
FacilityA hospital or hospital-owned outpatient department$7,079$4,074 to $12,023

How much rates vary

Facilitymedian $7,079 · 10th to 90th $2,344 to $16,982Professionalmedian $3,890 · 10th to 90th $1,000 to $7,943
$1.0K$2.0K$5.0K$10.0K$20.0K$50.0Kfacility $7,079professional $3,890

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$2,041.74
Median
$7,413.10
Typical High
$16,982.44
Aetna
Setting
Professional
Modifier
Global
Typical Low
$1,000.00
Median
$3,890.45
Typical High
$7,413.10
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$14,791.08
Median
$22,908.68
Typical High
$32,359.37
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$3,715.35
Median
$3,715.35
Typical High
$3,715.35
Cigna
Setting
Facility
Modifier
Global
Typical Low
$3,467.37
Median
$7,244.36
Typical High
$14,125.38
Cigna
Setting
Professional
Modifier
Global
Typical Low
$2,511.89
Median
$5,370.32
Typical High
$10,715.19
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$2,238.72
Median
$3,311.31
Typical High
$6,918.31
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$4,786.30
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$3,548.13
Median
$5,495.41
Typical High
$9,120.11
Highmark BCBS
Setting
Facility
Modifier
Global
Typical Low
$1,513.56
Median
$10,232.93
Typical High
$10,964.78
Highmark BCBS
Setting
Professional
Modifier
Global
Typical Low
$2,884.03
Median
$2,884.03
Typical High
$2,884.03
Independence Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$4,786.30
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$3,467.37
Median
$7,413.10
Typical High
$16,218.10
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$1,000.00
Median
$3,890.45
Typical High
$14,125.38
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$2,344.23
Median
$3,890.45
Typical High
$6,606.93
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$4,168.69
Median
$4,786.30
Typical High
$5,248.07
United
Setting
Facility
Modifier
Global
Typical Low
$2,398.83
Median
$4,786.30
Typical High
$5,754.40
United
Setting
Professional
Modifier
Global
Typical Low
$1,995.26
Median
$2,884.03
Typical High
$7,244.36

Where Pennsylvania sits

The same service costs 7.2 times more in North Dakota than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Pennsylvania $3,981 · 25th of 51
ND $7,244VT $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.