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Whole Exome Genetic Sequencing

Missouri rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$4,074

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $4,074 for this service. The price depends on where it is billed: about $3,548 from a physician practice, and about $8,318 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,548$2,884 to $6,166
FacilityA hospital or hospital-owned outpatient department$8,318$4,898 to $16,218

How much rates vary

Facilitymedian $8,318 · 10th to 90th $4,266 to $22,909Professionalmedian $3,548 · 10th to 90th $1,995 to $10,715
$1K$2K$5K$10K$20Kfacility $8,318professional $3,548

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$4,073.80
Median
$6,165.95
Typical High
$8,709.64
Aetna
Setting
Professional
Modifier
None
Typical Low
$4,073.80
Median
$4,073.80
Typical High
$5,495.41
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$21,877.62
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$1,905.46
Median
$2,884.03
Typical High
$8,709.64
BCBS Kansas City
Setting
Facility
Modifier
None
Typical Low
$6,606.93
Median
$7,413.10
Typical High
$13,182.57
BCBS Kansas City
Setting
Professional
Modifier
None
Typical Low
$3,311.31
Median
$4,786.30
Typical High
$9,120.11
Cigna
Setting
Facility
Modifier
None
Typical Low
$4,897.79
Median
$9,332.54
Typical High
$15,135.61
Cigna
Setting
Professional
Modifier
None
Typical Low
$2,290.87
Median
$5,370.32
Typical High
$6,918.31
Medica
Setting
Facility
Modifier
None
Typical Low
$4,168.69
Median
$8,317.64
Typical High
$22,908.68
Medica
Setting
Professional
Modifier
None
Typical Low
$2,398.83
Median
$5,011.87
Typical High
$23,988.33
United
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$4,265.80
Typical High
$4,265.80
United
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$2,884.03
Typical High
$6,456.54
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$2,041.74
Median
$2,041.74
Typical High
$2,754.23
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$812.83
Median
$812.83
Typical High
$1,096.48

Where Missouri sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 25th of 51

$4,074

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.