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Whole Exome Genetic Sequencing

Colorado rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$4,786

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $4,786 for this service. The price depends on where it is billed: about $3,311 from a physician practice, and about $13,804 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,311$1,995 to $4,786
FacilityA hospital or hospital-owned outpatient department$13,804$8,710 to $16,596

How much rates vary

Facilitymedian $13,804 · 10th to 90th $3,715 to $21,878Professionalmedian $3,311 · 10th to 90th $1,995 to $9,772
$2K$5K$10K$20Kfacility $13,804professional $3,311

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$4,786.30
Median
$10,000.00
Typical High
$21,877.62
Aetna
Setting
Professional
Modifier
None
Typical Low
$3,090.30
Median
$3,630.78
Typical High
$4,786.30
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$5,011.87
Median
$14,454.40
Typical High
$21,877.62
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$3,311.31
Typical High
$10,471.29
Cigna
Setting
Facility
Modifier
None
Typical Low
$2,570.40
Median
$5,754.40
Typical High
$15,135.61
Cigna
Setting
Professional
Modifier
None
Typical Low
$2,238.72
Median
$3,548.13
Typical High
$6,918.31
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$3,630.78
Median
$4,265.80
Typical High
$6,025.60
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$4,570.88
Median
$6,760.83
Typical High
$11,481.54
Select Health
Setting
Facility
Modifier
None
Typical Low
$4,786.30
Median
$8,912.51
Typical High
$10,000.00
Select Health
Setting
Professional
Modifier
None
Typical Low
$3,311.31
Median
$4,786.30
Typical High
$7,244.36
United
Setting
Facility
Modifier
None
Typical Low
$5,754.40
Median
$5,754.40
Typical High
$5,754.40
United
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$1,995.26
Typical High
$3,548.13
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$1,584.89
Median
$1,819.70
Typical High
$2,398.83
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$645.65
Median
$724.44
Typical High
$954.99

Where Colorado sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 15th of 51

$4,786

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.