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Whole Exome Genetic Sequencing

South Carolina rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$4,786

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $4,786 for this service. The price depends on where it is billed: about $4,786 from a physician practice, and about $6,026 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$4,786$3,020 to $4,786
FacilityA hospital or hospital-owned outpatient department$6,026$5,129 to $10,000

How much rates vary

Facilitymedian $6,026 · 10th to 90th $4,074 to $26,303Professionalmedian $4,786 · 10th to 90th $2,399 to $5,754
$2K$5K$10K$20Kfacility $6,026professional $4,786

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$3,715.35
Median
$3,715.35
Typical High
$3,715.35
Aetna
Setting
Professional
Modifier
None
Typical Low
$3,715.35
Median
$3,715.35
Typical High
$3,801.89
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$5,128.61
Median
$5,888.44
Typical High
$6,606.93
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$5,495.41
Cigna
Setting
Facility
Modifier
None
Typical Low
$9,120.11
Median
$12,022.64
Typical High
$29,512.09
Cigna
Setting
Professional
Modifier
None
Typical Low
$2,187.76
Median
$2,630.27
Typical High
$5,754.40
Medcost
Setting
Facility
Modifier
None
Typical Low
$3,311.31
Median
$4,466.84
Typical High
$6,309.57
Medcost
Setting
Professional
Modifier
None
Typical Low
$4,786.30
Median
$4,786.30
Typical High
$6,760.83
United
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$4,265.80
Typical High
$5,754.40
United
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$2,884.03
Typical High
$4,786.30
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$1,862.09
Median
$1,862.09
Typical High
$1,905.46
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$741.31
Median
$741.31
Typical High
$758.58
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$2,398.83
Median
$2,398.83
Typical High
$3,801.89

Where South Carolina sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 17th of 51

$4,786

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.