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Whole Exome Genetic Sequencing

Maryland rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated October 2026.

How much does Whole Exome Genetic Sequencing cost?

$3,548

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $3,548 for this service. Most negotiated rates run $3,236 to $3,802.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $3,311 · 10th to 90th $2,512 to $6,166Professionalmedian $3,548 · 10th to 90th $2,138 to $4,786
$2K$5K$10Kfacility $3,311professional $3,548

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$3,548.13
Median
$3,548.13
Typical High
$3,801.89
CareFirst
Setting
Professional
Modifier
None
Typical Low
$3,467.37
Median
$3,801.89
Typical High
$3,801.89
Cigna
Setting
Facility
Modifier
None
Typical Low
$2,511.89
Median
$3,311.31
Typical High
$6,165.95
Cigna
Setting
Professional
Modifier
None
Typical Low
$2,454.71
Median
$4,570.88
Typical High
$13,803.84
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$4,786.30
Median
$5,754.40
Typical High
$7,244.36
United
Setting
Professional
Modifier
None
Typical Low
$1,995.26
Median
$2,398.83
Typical High
$4,168.69
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$1,905.46
Median
$3,801.89
Typical High
$3,801.89
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$1,778.28
Median
$1,778.28
Typical High
$1,905.46
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$707.95
Median
$724.44
Typical High
$758.58

Where Maryland sits

The same service costs 10.7 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 35th of 51

$3,548

AK $10,715KY $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.