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Whole Exome Genetic Sequencing

Maryland rates for HCPCS 81415

Reads the protein-coding portions of essentially all of a person's genes from a blood or saliva sample, searching for a change that explains a condition present from birth or running in the family that has no clear cause. It is used when the features do not point to one suspected gene, so a broad search is more likely to find an answer than testing genes one at a time. A result may identify a cause, be inconclusive, or turn up a change whose meaning is not yet known.

Rates data updated July 2026.

How much does Whole Exome Genetic Sequencing cost?

$3,548

Typical negotiated rate. In Maryland, July 2026.

Insurers have agreed to pay about $3,548 for this service. The price depends on where it is billed: about $3,548 from a physician practice, and about $2,042 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,548$3,020 to $4,074
FacilityA hospital or hospital-owned outpatient department$2,042$2,042 to $3,236

How much rates vary

Facilitymedian $2,042 · 10th to 90th $1,995 to $4,074Professionalmedian $3,548 · 10th to 90th $2,042 to $6,166
$100.0$500.0$2.0K$10.0Kfacility $2,042professional $3,548

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$2,041.74
Median
$2,041.74
Typical High
$2,041.74
Aetna
Setting
Professional
Modifier
Global
Typical Low
$3,019.95
Median
$3,548.13
Typical High
$31,622.78
CareFirst
Setting
Professional
Modifier
Global
Typical Low
$3,467.37
Median
$3,630.78
Typical High
$4,265.80
Cigna
Setting
Facility
Modifier
Global
Typical Low
$2,511.89
Median
$3,311.31
Typical High
$6,165.95
Cigna
Setting
Professional
Modifier
Global
Typical Low
$2,511.89
Median
$3,388.44
Typical High
$8,511.38
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$4,786.30
Median
$5,754.40
Typical High
$7,244.36
United
Setting
Facility
Modifier
Global
Typical Low
$1,995.26
Median
$2,290.87
Typical High
$4,786.30
United
Setting
Professional
Modifier
Global
Typical Low
$1,995.26
Median
$2,137.96
Typical High
$4,466.84
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$1,905.46
Median
$3,311.31
Typical High
$4,786.30

Where Maryland sits

The same service costs 7.2 times more in North Dakota than in Vermont. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Maryland $3,548 · 43rd of 51
ND $7,244VT $1,000

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.