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Detailed Immune Marker Typing, Class I And II

Nationwide rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated July 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$347

Typical negotiated rate. Nationwide, July 2026.

Insurers have agreed to pay about $347 for this service. The price depends on where it is billed: about $309 from a physician practice, and about $617 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 71 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$309$257 to $427
FacilityA hospital or hospital-owned outpatient department$617$347 to $1,047

How much rates vary

Facilitymedian $617 · 10th to 90th $302 to $1,738Professionalmedian $309 · 10th to 90th $191 to $741
$10$100$1Kfacility $617professional $309

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$281.84
Median
$645.65
Typical High
$1,819.70
Aetna
Setting
Professional
Modifier
Global
Typical Low
$239.88
Median
$295.12
Typical High
$707.95
BCBS
Setting
Facility
Modifier
Global
Typical Low
$346.74
Median
$512.86
Typical High
$1,584.89
BCBS
Setting
Professional
Modifier
Global
Typical Low
$169.82
Median
$295.12
Typical High
$851.14
Cigna
Setting
Facility
Modifier
Global
Typical Low
$302.00
Median
$741.31
Typical High
$1,584.89
Cigna
Setting
Professional
Modifier
Global
Typical Low
$181.97
Median
$416.87
Typical High
$831.76
United
Setting
Facility
Modifier
Global
Typical Low
$199.53
Median
$346.74
Typical High
$467.74
United
Setting
Professional
Modifier
Global
Typical Low
$144.54
Median
$208.93
Typical High
$549.54

What it costs in each state

The same service costs 3.1 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Touch or drag across the chart to see any state's rate.

AK $776DE $251

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.