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Detailed Immune Marker Typing, Class I And II

Minnesota rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated October 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$347

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $347 for this service. The price depends on where it is billed: about $347 from a physician practice, and about $603 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$347$302 to $437
FacilityA hospital or hospital-owned outpatient department$603$324 to $708

How much rates vary

Facilitymedian $603 · 10th to 90th $324 to $1,175Professionalmedian $347 · 10th to 90th $240 to $708
$200$500$1K$2Kfacility $603professional $347

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$323.59
Median
$323.59
Typical High
$602.56
Aetna
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$323.59
Typical High
$416.87
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$346.74
Typical High
$933.25
BCBS Minnesota
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$309.03
Typical High
$346.74
Cigna
Setting
Facility
Modifier
None
Typical Low
$691.83
Median
$1,096.48
Typical High
$3,235.94
Cigna
Setting
Professional
Modifier
None
Typical Low
$398.11
Median
$457.09
Typical High
$676.08
Health Partners
Setting
Facility
Modifier
None
Typical Low
$645.65
Median
$1,071.52
Typical High
$2,511.89
Health Partners
Setting
Professional
Modifier
None
Typical Low
$398.11
Median
$398.11
Typical High
$660.69
Medica
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$630.96
Typical High
$870.96
Medica
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$389.05
Typical High
$1,737.80
United
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$346.74
Typical High
$416.87
United
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$281.84
Typical High
$812.83
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$162.18
Median
$162.18
Typical High
$162.18
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$64.57
Median
$64.57
Typical High
$64.57
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$162.18
Median
$162.18
Typical High
$208.93
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$64.57
Median
$64.57
Typical High
$83.18

Where Minnesota sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 29th of 51

$347

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.