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Detailed Immune Marker Typing, Class I And II

Iowa rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated October 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$380

Typical negotiated rate. In Iowa, October 2026.

Insurers have agreed to pay about $380 for this service. The price depends on where it is billed: about $355 from a physician practice, and about $661 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$355$269 to $741
FacilityA hospital or hospital-owned outpatient department$661$417 to $912

How much rates vary

Facilitymedian $661 · 10th to 90th $347 to $977Professionalmedian $355 · 10th to 90th $209 to $1,738
$200$500$1K$2Kfacility $661professional $355

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$724.44
Typical High
$977.24
Aetna
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$269.15
Typical High
$416.87
Cigna
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$660.69
Typical High
$977.24
Hally Health
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$436.52
Typical High
$2,187.76
Medica
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$676.08
Typical High
$977.24
Medica
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$416.87
Typical High
$1,737.80
Midlands
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$457.09
Oscar Health
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$371.54
Typical High
$741.31
United
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$346.74
Typical High
$891.25
United
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$208.93
Typical High
$831.76
Wellmark
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$346.74
Typical High
$346.74
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$134.90
Median
$134.90
Typical High
$208.93
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$53.70
Median
$53.70
Typical High
$83.18

Where Iowa sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 22nd of 51

$380

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.