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Detailed Immune Marker Typing, Class I And II

South Dakota rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated July 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$631

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $631 for this service. The price depends on where it is billed: about $513 from a physician practice, and about $661 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$513$269 to $832
FacilityA hospital or hospital-owned outpatient department$661$550 to $661

How much rates vary

Facilitymedian $661 · 10th to 90th $389 to $661Professionalmedian $513 · 10th to 90th $229 to $933
$200.0$500.0$1.0Kfacility $661professional $513

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$239.88
Median
$389.05
Typical High
$389.05
Aetna
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$269.15
Typical High
$323.59
Avera
Setting
Facility
Modifier
Global
Typical Low
$346.74
Median
$346.74
Typical High
$512.86
Cigna
Setting
Facility
Modifier
Global
Typical Low
$660.69
Median
$660.69
Typical High
$660.69
Cigna
Setting
Professional
Modifier
Global
Typical Low
$501.19
Median
$660.69
Typical High
$831.76
Medica
Setting
Facility
Modifier
Global
Typical Low
$323.59
Median
$389.05
Typical High
$1,318.26
Medica
Setting
Professional
Modifier
Global
Typical Low
$208.93
Median
$239.88
Typical High
$1,737.80
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$512.86
Median
$831.76
Typical High
$954.99
United
Setting
Professional
Modifier
Global
Typical Low
$144.54
Median
$239.88
Typical High
$467.74
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$346.74
Median
$346.74
Typical High
$346.74

Where South Dakota sits

The same service costs 3.1 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

South Dakota $631 · 2nd of 51
AK $776DE $251

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.