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Detailed Immune Marker Typing, Class I And II

Massachusetts rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated October 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$417

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $417 for this service. The price depends on where it is billed: about $347 from a physician practice, and about $525 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$347$282 to $871
FacilityA hospital or hospital-owned outpatient department$525$372 to $1,000

How much rates vary

Facilitymedian $525 · 10th to 90th $316 to $1,230Professionalmedian $347 · 10th to 90th $209 to $1,738
$100$200$500$1K$2K$5Kfacility $525professional $347

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$660.69
Typical High
$1,479.11
Aetna
Setting
Professional
Modifier
None
Typical Low
$331.13
Median
$331.13
Typical High
$380.19
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$489.78
Typical High
$1,122.02
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$660.69
Typical High
$1,737.80
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$676.08
Median
$954.99
Typical High
$1,380.38
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$323.59
Typical High
$446.68
Cigna
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$467.74
Typical High
$724.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$363.08
Typical High
$1,348.96
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$588.84
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$489.78
Median
$489.78
Typical High
$588.84
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$346.74
Typical High
$1,096.48
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$489.78
Typical High
$1,122.02
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$660.69
Typical High
$1,737.80
United
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$346.74
Typical High
$416.87
United
Setting
Professional
Modifier
None
Typical Low
$138.04
Median
$208.93
Typical High
$691.83
Well Sense
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$426.58
Typical High
$630.96
Well Sense
Setting
Professional
Modifier
None
Typical Low
$354.81
Median
$354.81
Typical High
$426.58
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$165.96
Median
$165.96
Typical High
$165.96
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$66.07
Median
$66.07
Typical High
$66.07
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$346.74
Median
$446.68
Typical High
$537.03

Where Massachusetts sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 15th of 51

$417

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.