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Detailed Immune Marker Typing, Class I And II

Virginia rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated October 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$324

Typical negotiated rate. In Virginia, October 2026.

Insurers have agreed to pay about $324 for this service. The price depends on where it is billed: about $282 from a physician practice, and about $513 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$282$209 to $363
FacilityA hospital or hospital-owned outpatient department$513$347 to $851

How much rates vary

Facilitymedian $513 · 10th to 90th $347 to $1,820Professionalmedian $282 · 10th to 90th $170 to $646
$100$200$500$1K$2K$5K$10Kfacility $513professional $282

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$323.59
Typical High
$891.25
Aetna
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$257.04
Typical High
$323.59
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$346.74
Typical High
$1,698.24
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$169.82
Median
$208.93
Typical High
$309.03
CareFirst
Setting
Professional
Modifier
None
Typical Low
$281.84
Median
$309.03
Typical High
$467.74
Cigna
Setting
Facility
Modifier
None
Typical Low
$354.81
Median
$676.08
Typical High
$1,202.26
Cigna
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$257.04
Typical High
$676.08
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$331.13
Median
$380.19
Typical High
$478.63
Medcost
Setting
Facility
Modifier
None
Typical Low
$630.96
Median
$630.96
Typical High
$691.83
Medcost
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$467.74
Sentara
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$575.44
Typical High
$10,232.93
Sentara
Setting
Professional
Modifier
None
Typical Low
$331.13
Median
$501.19
Typical High
$7,413.10
United
Setting
Facility
Modifier
None
Typical Low
$416.87
Median
$416.87
Typical High
$416.87
United
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$208.93
Typical High
$537.03
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$128.82
Median
$128.82
Typical High
$162.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$51.29
Median
$51.29
Typical High
$64.57

Where Virginia sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Virginia· 39th of 51

$324

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.