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Detailed Immune Marker Typing, Class I And II

Colorado rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated October 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$457

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $457 for this service. The price depends on where it is billed: about $214 from a physician practice, and about $1,000 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$214$145 to $447
FacilityA hospital or hospital-owned outpatient department$1,000$631 to $1,202

How much rates vary

Facilitymedian $1,000 · 10th to 90th $269 to $1,585Professionalmedian $214 · 10th to 90th $145 to $708
$200$500$1K$2Kfacility $1,000professional $214

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$602.56
Typical High
$1,584.89
Aetna
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$263.03
Typical High
$446.68
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$1,047.13
Typical High
$1,584.89
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$144.54
Typical High
$758.58
Cigna
Setting
Facility
Modifier
None
Typical Low
$204.17
Median
$416.87
Typical High
$1,096.48
Cigna
Setting
Professional
Modifier
None
Typical Low
$165.96
Median
$213.80
Typical High
$501.19
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$331.13
Typical High
$616.60
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$489.78
Typical High
$891.25
Select Health
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$645.65
Typical High
$724.44
Select Health
Setting
Professional
Modifier
None
Typical Low
$239.88
Median
$346.74
Typical High
$512.86
United
Setting
Facility
Modifier
None
Typical Low
$416.87
Median
$416.87
Typical High
$416.87
United
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$199.53
Typical High
$257.04
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$128.82
Median
$131.83
Typical High
$213.80
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$51.29
Median
$52.48
Typical High
$85.11

Where Colorado sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 9th of 51

$457

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.