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Detailed Immune Marker Typing, Class I And II

North Carolina rates for HCPCS 81378

This genetic test identifies a person's specific immune-system marker genes across both the Class I and Class II groups together, at a highly detailed level of resolution. These markers play an important role in how the immune system recognizes foreign material, and precise matching of them between a donor and recipient is especially important for bone marrow and stem cell transplants. The detailed level of testing allows for more precise matching than a basic-level test.

Rates data updated October 2026.

How much does Detailed Immune Marker Typing, Class I And II cost?

$427

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $427 for this service. The price depends on where it is billed: about $427 from a physician practice, and about $741 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$427$309 to $468
FacilityA hospital or hospital-owned outpatient department$741$275 to $1,202

How much rates vary

Facilitymedian $741 · 10th to 90th $275 to $1,585Professionalmedian $427 · 10th to 90th $170 to $617
$200$500$1Kfacility $741professional $427

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$776.25
Aetna
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$416.87
Ambetter
Setting
Professional
Modifier
None
Typical Low
$489.78
Median
$489.78
Typical High
$489.78
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$776.25
Median
$1,047.13
Typical High
$1,230.27
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$426.58
Typical High
$616.60
Cigna
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$758.58
Typical High
$1,584.89
Cigna
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$316.23
Typical High
$512.86
Medcost
Setting
Facility
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$407.38
Medcost
Setting
Professional
Modifier
None
Typical Low
$467.74
Median
$467.74
Typical High
$691.83
United
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$234.42
Typical High
$467.74
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$138.04
Median
$138.04
Typical High
$208.93
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$54.95
Median
$54.95
Typical High
$83.18
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$234.42
Median
$234.42
Typical High
$478.63

Where North Carolina sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 13th of 51

$427

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.