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Light-Activated Drug Treatment for Retina Vessels

Missouri rates for HCPCS 67221

This is a treatment for abnormal blood vessel growth beneath the retina, often related to macular degeneration, where a light-sensitive medication is given through an intravenous line and then activated with a special low-energy light aimed into the eye. Activating the medication seals off the abnormal vessels while sparing the surrounding healthy retinal tissue.

Rates data updated July 2026.

How much does Light-Activated Drug Treatment for Retina Vessels cost?

$457

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $457 for this service. The price depends on where it is billed: about $302 from a physician practice, and about $1,778 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$302$251 to $380
FacilityA hospital or hospital-owned outpatient department$1,778$1,072 to $3,162

How much rates vary

Facilitymedian $1,778 · 10th to 90th $339 to $5,248Professionalmedian $302 · 10th to 90th $214 to $891
$100.0$200.0$500.0$1.0K$2.0K$5.0K$10.0Kfacility $1,778professional $302

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$281.84
Median
$2,398.83
Typical High
$6,309.57
Aetna
Setting
Professional
Modifier
Global
Typical Low
$213.80
Median
$288.40
Typical High
$1,698.24
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$676.08
Median
$1,819.70
Typical High
$3,981.07
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$218.78
Median
$309.03
Typical High
$478.63
BCBS
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$281.84
Typical High
$457.09
Cigna
Setting
Facility
Modifier
Global
Typical Low
$165.96
Median
$165.96
Typical High
$389.05
Cigna
Setting
Professional
Modifier
Global
Typical Low
$213.80
Median
$323.59
Typical High
$562.34
Medica
Setting
Facility
Modifier
Global
Typical Low
$54.95
Median
$467.74
Typical High
$1,819.70
Medica
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$398.11
Typical High
$2,041.74
United
Setting
Facility
Modifier
Global
Typical Low
$436.52
Median
$1,047.13
Typical High
$2,089.30
United
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$295.12
Typical High
$501.19

Where Missouri sits

The same service costs 3.8 times more in Wyoming than in West Virginia. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Missouri $457 · 8th of 51
WY $977WV $257

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.