go back

Light-Activated Drug Treatment for Retina Vessels

Missouri rates for HCPCS 67221

This is a treatment for abnormal blood vessel growth beneath the retina, often related to macular degeneration, where a light-sensitive medication is given through an intravenous line and then activated with a special low-energy light aimed into the eye. Activating the medication seals off the abnormal vessels while sparing the surrounding healthy retinal tissue.

Rates data updated October 2026.

How much does Light-Activated Drug Treatment for Retina Vessels cost?

$339

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $339 for this service. The price depends on where it is billed: about $316 from a physician practice, and about $1,148 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$316$245 to $479
FacilityA hospital or hospital-owned outpatient department$1,148$389 to $1,905

How much rates vary

Facilitymedian $1,148 · 10th to 90th $170 to $3,548Professionalmedian $316 · 10th to 90th $214 to $1,549
$100$200$500$1K$2K$5Kfacility $1,148professional $316

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$323.59
Median
$3,162.28
Typical High
$7,762.47
Aetna
Setting
Professional
Modifier
None
Typical Low
$213.80
Median
$281.84
Typical High
$331.13
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$151.36
Median
$1,621.81
Typical High
$3,890.45
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$323.59
Typical High
$478.63
BCBS Kansas City
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$281.84
Typical High
$316.23
Cigna
Setting
Facility
Modifier
None
Typical Low
$162.18
Median
$245.47
Typical High
$1,659.59
Cigna
Setting
Professional
Modifier
None
Typical Low
$199.53
Median
$263.03
Typical High
$436.52
Medica
Setting
Facility
Modifier
None
Typical Low
$54.95
Median
$776.25
Typical High
$1,819.70
Medica
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$1,548.82
Typical High
$2,041.74
United
Setting
Facility
Modifier
None
Typical Low
$398.11
Median
$1,148.15
Typical High
$2,238.72
United
Setting
Professional
Modifier
None
Typical Low
$194.98
Median
$288.40
Typical High
$467.74
5 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$107.15
Median
$134.90
Typical High
$162.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$42.66
Median
$53.70
Typical High
$64.57
Aetna
Setting
Professional
Modifier
54 · Surgery only
Typical Low
$162.18
Median
$204.17
Typical High
$245.47
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$32.36
Median
$40.74
Typical High
$48.98
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$21.38
Median
$26.92
Typical High
$32.36

Where Missouri sits

The same service costs 3.5 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 23rd of 51

$339

AK $832FL $234

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.