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Light-Activated Drug Treatment for Retina Vessels

Minnesota rates for HCPCS 67221

This is a treatment for abnormal blood vessel growth beneath the retina, often related to macular degeneration, where a light-sensitive medication is given through an intravenous line and then activated with a special low-energy light aimed into the eye. Activating the medication seals off the abnormal vessels while sparing the surrounding healthy retinal tissue.

Rates data updated October 2026.

How much does Light-Activated Drug Treatment for Retina Vessels cost?

$513

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $513 for this service. The price depends on where it is billed: about $513 from a physician practice, and about $646 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$513$347 to $676
FacilityA hospital or hospital-owned outpatient department$646$302 to $1,148

How much rates vary

Facilitymedian $646 · 10th to 90th $219 to $2,188Professionalmedian $513 · 10th to 90th $282 to $955
$200$500$1K$2K$5Kfacility $646professional $513

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$218.78
Median
$302.00
Typical High
$302.00
Aetna
Setting
Professional
Modifier
None
Typical Low
$218.78
Median
$281.84
Typical High
$302.00
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$1,778.28
Typical High
$4,073.80
BCBS Minnesota
Setting
Professional
Modifier
None
Typical Low
$302.00
Median
$524.81
Typical High
$851.14
Cigna
Setting
Facility
Modifier
None
Typical Low
$467.74
Median
$724.44
Typical High
$1,380.38
Cigna
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$602.56
Typical High
$1,047.13
Health Partners
Setting
Facility
Modifier
None
Typical Low
$416.87
Median
$691.83
Typical High
$1,174.90
Health Partners
Setting
Professional
Modifier
None
Typical Low
$338.84
Median
$575.44
Typical High
$977.24
Medica
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$676.08
Typical High
$2,089.30
Medica
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$575.44
Typical High
$2,041.74
United
Setting
Facility
Modifier
None
Typical Low
$549.54
Median
$1,000.00
Typical High
$3,162.28
United
Setting
Professional
Modifier
None
Typical Low
$263.03
Median
$436.52
Typical High
$912.01
10 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$109.65
Median
$151.36
Typical High
$151.36
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$43.65
Median
$60.26
Typical High
$60.26
Aetna
Setting
Facility
Modifier
54 · Surgery only
Typical Low
$165.96
Median
$223.87
Typical High
$223.87
Aetna
Setting
Facility
Modifier
55 · Aftercare only
Typical Low
$33.11
Median
$44.67
Typical High
$44.67
Aetna
Setting
Facility
Modifier
56 · Pre-op care only
Typical Low
$21.88
Median
$30.20
Typical High
$30.20
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$109.65
Median
$141.25
Typical High
$151.36
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$43.65
Median
$57.54
Typical High
$60.26
Aetna
Setting
Professional
Modifier
54 · Surgery only
Typical Low
$165.96
Median
$213.80
Typical High
$223.87
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$33.11
Median
$42.66
Typical High
$44.67
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$21.88
Median
$28.84
Typical High
$30.20

Where Minnesota sits

The same service costs 3.5 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 5th of 51

$513

AK $832FL $234

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.