go back

Light-Activated Drug Treatment for Retina Vessels

South Dakota rates for HCPCS 67221

This is a treatment for abnormal blood vessel growth beneath the retina, often related to macular degeneration, where a light-sensitive medication is given through an intravenous line and then activated with a special low-energy light aimed into the eye. Activating the medication seals off the abnormal vessels while sparing the surrounding healthy retinal tissue.

Rates data updated October 2026.

How much does Light-Activated Drug Treatment for Retina Vessels cost?

$457

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $457 for this service. The price depends on where it is billed: about $468 from a physician practice, and about $398 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$468$339 to $603
FacilityA hospital or hospital-owned outpatient department$398$295 to $525

How much rates vary

Facilitymedian $398 · 10th to 90th $214 to $759Professionalmedian $468 · 10th to 90th $240 to $794
$200$500$1K$2Kfacility $398professional $468

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$281.84
Typical High
$4,365.16
Aetna
Setting
Professional
Modifier
None
Typical Low
$177.83
Median
$239.88
Typical High
$316.23
Cigna
Setting
Facility
Modifier
None
Typical Low
$199.53
Median
$234.42
Typical High
$524.81
Cigna
Setting
Professional
Modifier
None
Typical Low
$338.84
Median
$537.03
Typical High
$831.76
Medica
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$398.11
Typical High
$758.58
Medica
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$602.56
Typical High
$1,548.82
Midlands
Setting
Professional
Modifier
None
Typical Low
$501.19
Median
$660.69
Typical High
$660.69
Midlands
Setting
Facility
Modifier
None
Typical Low
$199.53
Median
$223.87
Typical High
$263.03
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$295.12
Median
$436.52
Typical High
$575.44
United
Setting
Facility
Modifier
None
Typical Low
$446.68
Median
$537.03
Typical High
$758.58
United
Setting
Professional
Modifier
None
Typical Low
$245.47
Median
$501.19
Typical High
$794.33
Wellmark
Setting
Professional
Modifier
None
Typical Low
$354.81
Median
$426.58
Typical High
$724.44
5 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$89.13
Median
$117.49
Typical High
$151.36
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$35.48
Median
$47.86
Typical High
$60.26
Aetna
Setting
Professional
Modifier
54 · Surgery only
Typical Low
$134.90
Median
$177.83
Typical High
$223.87
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$26.92
Median
$35.48
Typical High
$44.67
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$17.78
Median
$23.99
Typical High
$30.20

Where South Dakota sits

The same service costs 3.5 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 6th of 51

$457

AK $832FL $234

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.