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Light-Activated Drug Treatment for Retina Vessels

South Carolina rates for HCPCS 67221

This is a treatment for abnormal blood vessel growth beneath the retina, often related to macular degeneration, where a light-sensitive medication is given through an intravenous line and then activated with a special low-energy light aimed into the eye. Activating the medication seals off the abnormal vessels while sparing the surrounding healthy retinal tissue.

Rates data updated October 2026.

How much does Light-Activated Drug Treatment for Retina Vessels cost?

$324

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $324 for this service. The price depends on where it is billed: about $295 from a physician practice, and about $1,122 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$295$263 to $398
FacilityA hospital or hospital-owned outpatient department$1,122$437 to $2,291

How much rates vary

Facilitymedian $1,122 · 10th to 90th $245 to $3,981Professionalmedian $295 · 10th to 90th $195 to $479
$200$500$1K$2K$5K$10Kfacility $1,122professional $295

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$4,897.79
Typical High
$21,877.62
Aetna
Setting
Professional
Modifier
None
Typical Low
$251.19
Median
$269.15
Typical High
$338.84
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$891.25
Median
$1,513.56
Typical High
$2,691.53
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$162.18
Median
$295.12
Typical High
$407.38
Cigna
Setting
Facility
Modifier
None
Typical Low
$186.21
Median
$389.05
Typical High
$707.95
Cigna
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$269.15
Typical High
$457.09
Medcost
Setting
Facility
Modifier
None
Typical Low
$208.93
Median
$281.84
Typical High
$371.54
Medcost
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$323.59
Typical High
$371.54
Molina
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$389.05
Typical High
$501.19
United
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$1,122.02
Typical High
$6,025.60
United
Setting
Professional
Modifier
None
Typical Low
$199.53
Median
$275.42
Typical High
$478.63
6 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$128.82
Median
$131.83
Typical High
$169.82
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$52.48
Median
$52.48
Typical High
$67.61
Aetna
Setting
Professional
Modifier
54 · Surgery only
Typical Low
$194.98
Median
$194.98
Typical High
$257.04
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$38.90
Median
$39.81
Typical High
$51.29
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$26.30
Median
$26.30
Typical High
$33.88
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$162.18
Median
$169.82
Typical High
$194.98

Where South Carolina sits

The same service costs 3.5 times more in Alaska than in Florida. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 29th of 51

$324

AK $832FL $234

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.