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Alpha Globin Known Family Variant Test

Nationwide rates for HCPCS 81258

A blood test that checks for one specific change in an alpha globin gene that has already been identified in the family. These genes make part of hemoglobin, the oxygen-carrying protein in red blood cells, and changes in them cause alpha thalassemia, an inherited form of anemia.

Rates data updated July 2026.

Facilitymedian $550 · 10th–90th $302$1,6220%10%20%10th90th$550Professionalmedian $316 · 10th–90th $174$7240%10%20%10th90th$316$0.5$5.0$50.0$500.0$5.0K$50.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$302.00
Median
$602.56
Typical High
$1,621.81
Aetna
Setting
Professional
Modifier
Global
Typical Low
$223.87
Median
$309.03
Typical High
$691.83
BCBS
Setting
Facility
Modifier
Global
Typical Low
$338.84
Median
$501.19
Typical High
$1,698.24
BCBS
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$208.93
Typical High
$707.95
Cigna
Setting
Facility
Modifier
Global
Typical Low
$269.15
Median
$758.58
Typical High
$1,621.81
Cigna
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$426.58
Typical High
$891.25
United
Setting
Facility
Modifier
Global
Typical Low
$177.83
Median
$371.54
Typical High
$446.68
United
Setting
Professional
Modifier
Global
Typical Low
$158.49
Median
$223.87
Typical High
$562.34