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Alpha Globin Known Family Variant Test

South Dakota rates for HCPCS 81258

A blood test that checks for one specific change in an alpha globin gene that has already been identified in the family. These genes make part of hemoglobin, the oxygen-carrying protein in red blood cells, and changes in them cause alpha thalassemia, an inherited form of anemia.

Rates data updated October 2026.

How much does Alpha Globin Known Family Variant Test cost?

$427

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $427 for this service. The price depends on where it is billed: about $372 from a physician practice, and about $427 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$372$263 to $724
FacilityA hospital or hospital-owned outpatient department$427$427 to $724

How much rates vary

Facilitymedian $427 · 10th to 90th $363 to $724Professionalmedian $372 · 10th to 90th $191 to $891
$200$500$1Kfacility $427professional $372

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$263.03
Typical High
$426.58
Aetna
Setting
Professional
Modifier
None
Typical Low
$251.19
Median
$251.19
Typical High
$354.81
Cigna
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$724.44
Typical High
$724.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$724.44
Typical High
$891.25
Medica
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$426.58
Typical High
$426.58
Medica
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$338.84
Typical High
$691.83
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$562.34
Median
$870.96
Typical High
$1,023.29
United
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$223.87
Typical High
$371.54
Wellmark
Setting
Professional
Modifier
None
Typical Low
$371.54
Median
$371.54
Typical High
$371.54

Where South Dakota sits

The same service costs 6.5 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 12th of 51

$427

TX $1,122AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.