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Alpha Globin Known Family Variant Test

Pennsylvania rates for HCPCS 81258

A blood test that checks for one specific change in an alpha globin gene that has already been identified in the family. These genes make part of hemoglobin, the oxygen-carrying protein in red blood cells, and changes in them cause alpha thalassemia, an inherited form of anemia.

Rates data updated July 2026.

Facilitymedian $724 · 10th–90th $316$1,4130%10%10th90th$724Professionalmedian $302 · 10th–90th $200$8320%20%10th90th$302$100.0$500.0$2.0K$10.0K$50.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$316.23
Median
$724.44
Typical High
$1,348.96
Aetna
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$302.00
Typical High
$1,348.96
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$1,348.96
Median
$1,862.09
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$295.12
Median
$295.12
Typical High
$295.12
Cigna
Setting
Facility
Modifier
Global
Typical Low
$363.08
Median
$616.60
Typical High
$1,288.25
Cigna
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$323.59
Typical High
$660.69
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$263.03
Median
$263.03
Typical High
$489.78
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$371.54
Median
$371.54
Typical High
$371.54
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$281.84
Median
$436.52
Typical High
$707.95
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$302.00
Median
$724.44
Typical High
$1,288.25
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$302.00
Typical High
$1,348.96
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$371.54
Median
$416.87
Typical High
$933.25
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$371.54
Median
$371.54
Typical High
$416.87
United
Setting
Facility
Modifier
Global
Typical Low
$338.84
Median
$371.54
Typical High
$446.68
United
Setting
Professional
Modifier
Global
Typical Low
$158.49
Median
$223.87
Typical High
$562.34