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Alpha Globin Known Family Variant Test

Indiana rates for HCPCS 81258

A blood test that checks for one specific change in an alpha globin gene that has already been identified in the family. These genes make part of hemoglobin, the oxygen-carrying protein in red blood cells, and changes in them cause alpha thalassemia, an inherited form of anemia.

Rates data updated October 2026.

How much does Alpha Globin Known Family Variant Test cost?

$295

Typical negotiated rate. In Indiana, October 2026.

Insurers have agreed to pay about $295 for this service. The price depends on where it is billed: about $224 from a physician practice, and about $372 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$224$151 to $363
FacilityA hospital or hospital-owned outpatient department$372$339 to $759

How much rates vary

Facilitymedian $372 · 10th to 90th $295 to $1,122Professionalmedian $224 · 10th to 90th $151 to $562
$200$500$1K$2Kfacility $372professional $224

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$562.34
Typical High
$1,380.38
Aetna
Setting
Professional
Modifier
None
Typical Low
$281.84
Median
$309.03
Typical High
$562.34
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$295.12
Median
$371.54
Typical High
$1,122.02
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$151.36
Typical High
$562.34
Cigna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$371.54
Typical High
$1,071.52
Cigna
Setting
Professional
Modifier
None
Typical Low
$169.82
Median
$338.84
Typical High
$724.44
Physicians Health Plan of Northern Indiana
Setting
Facility
Modifier
None
Typical Low
$616.60
Median
$912.01
Typical High
$2,187.76
Physicians Health Plan of Northern Indiana
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$309.03
Typical High
$575.44
United
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$223.87
Typical High
$446.68
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$141.25
Median
$154.88
Typical High
$281.84
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$56.23
Median
$61.66
Typical High
$112.20

Where Indiana sits

The same service costs 6.5 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Indiana· 42nd of 51

$295

TX $1,122AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.