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Lyme Disease Bacterial Protein Urine Test

Nationwide rates for HCPCS 0316U

Tests for Lyme disease by looking directly for OspA, a protein made by the Borrelia burgdorferi bacterium, in a urine sample, and reports whether it is found. Unlike most Lyme testing, it detects a protein made by the bacterium itself rather than the antibodies your immune system makes against it or the bacterium's genetic material.

Rates data updated July 2026.

Facilitymedian $27 · 10th–90th $14$870%10%20%10th90th$27Professionalmedian $14 · 10th–90th $8$250%20%10th90th$14$2.0$10.0$50.0$200.0$1.0K$5.0K$20.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$14.79
Median
$30.20
Typical High
$81.28
Aetna
Setting
Professional
Modifier
Global
Typical Low
$11.22
Median
$14.45
Typical High
$18.62
BCBS
Setting
Facility
Modifier
Global
Typical Low
$15.85
Median
$35.48
Typical High
$93.33
BCBS
Setting
Professional
Modifier
Global
Typical Low
$7.59
Median
$8.71
Typical High
$22.39
Cigna
Setting
Facility
Modifier
Global
Typical Low
$12.88
Median
$36.31
Typical High
$83.18
Cigna
Setting
Professional
Modifier
Global
Typical Low
$21.38
Median
$27.54
Typical High
$45.71
United
Setting
Facility
Modifier
Global
Typical Low
$7.76
Median
$18.62
Typical High
$22.39
United
Setting
Professional
Modifier
Global
Typical Low
$7.76
Median
$11.22
Typical High
$22.39